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The mechanism of action has been determined that KPV inhibits the activation of NF-kappaB and MAP kinase inflammatory signaling pathways, and reduces pro-inflammatory cytokine secretionacts via PepT1 expressed in immune and intestinal epithelial cells..[and] reduces the incidence of DSS- and TNBS-induced colitis indicated by a decrease in pro-inflammatory cytokine expression (Dalmasso et al., 2008)

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Biochem Biophys Res Commun 350:147150 Veljaca M, Chan K, Guglietta A (1995) Digestion of h-EGF, h-TGF alpha and BPC-15 in human gastric juice